Absolute stereochemistry of antifouling cembranoid epimers at C-8 from the Caribbean octocoral Pseudoplexaura flagellosa . Revised structures of plexaurolones | Semantic Scholar (2024)

This paper reports for first time the use of VCD in briarane diterpenes and with the presence of chlorine atoms.

Three new cembranoid diterpenes, knightine, knightal, and 11(R)-hydroxy-12(20)-en-knightal, were isolated as minor constituents of the Caribbean gorgonian Eunicea knighti and determined by detailed spectroscopic analyses and combination of chemical transformations and modified Mosher's methods.

A comparative study between high-resolution proton nuclear magnetic resonance (1H-NMR) and pure shift yielded by chirp excitation (PSYCHE) experiments to analyze the metabolic profile of 24 soft corals reveals that when a decoupled experiment is performed, it was possible to establish a statistically valid correlation between the chemical composition ofsoft corals and their cytotoxic activity against the PC3 cancer cell line.

This chapter presents some significant study cases on octocoral organisms that have been identified as a source of promising bioactive compounds and whose results have further been used for studies on structure-activity relationship (SAR) as a strategy to increase the value of the activity initially detected.

5 meroterpenoids from Aplidium aff.

5 meroterpenoids from Aplidium aff.

This mini-review excludes more than 200 compounds that were also reported as AF compounds but with rather weak bioactivity during the same period, and also excluded are terrestrial-derived AF compounds reported during the last five years.

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Three new cembranoid diterpenes, knightol, knightal, and knightal were isolated as major compounds from the sea whip Eunicea knighti collected from the Colombian Caribbean and showed significant antimicrobial activity against bacterial isolates and excellent anti-QS inhibition activity measured by means of bioluminescence inhibition with biosensor model systems.

Seven new compounds, designated as limazepines A, B1 and B2 (isolated as an isomeric mixture), C, D, E, and F, from the culture broth of Micrococcus sp.

The extract of octocoral Eunicea laciniata organic extract showed antifouling activity against five strains of marine bacteria associated to heavy fouled surfaces and low toxicity in Artemia salina test.

Six new cembrane derivatives of α-methylene-δ-lactone derivatives were isolated from the lipid extract of the Caribbean gorgonian Eumicea mammosa, and the structures of these were determined by means of spectroscopic analyses.

This is the first report of cembrene A from a vertebrate; the ketone has not been described previously.

The laboratory bioassays that have been developed for studying the control of algae and invertebrates by epibiosis and the screening of new active compounds to inhibit settlement or adhesion, ie fouling-release coatings are reviewed.

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